Approximate Multiple Protein Structure Alignment Using the Sum-of-Pairs Distance

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Approximate Multiple Protein Structure Alignment Using the Sum-of-Pairs Distance

An algorithm is presented to compute a multiple structure alignment for a set of proteins and to generate a consensus (pseudo) protein for the set. The algorithm is a heuristic in that it computes an approximation to the optimal multiple structure alignment that minimizes the sum of the pairwise distances between the protein structures. The algorithm chooses an input protein as the initial cons...

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ژورنال

عنوان ژورنال: Journal of Computational Biology

سال: 2004

ISSN: 1066-5277,1066-5277

DOI: 10.1089/1066527042432198